Scientific Studies & Articles Supporting Nasal Irrigation

From symptom relief to illness prevention, hunderds of clinical studies and research projects have been conducted with positive outcomes on various aspects of nasal washing.

Rabago D, Zgierska A, Mundt M, Barrett B, Bobula J, Maberry R. Efficacy of daily hypertonic saline irrigation among patients with sinusitis: a randomized controlled trial. Journal Family Practice 51(12): 1049-55, 2002 De

Bothwell MR, Parsons DS: Pediatric Chronic Rhinosinusits: A Step-Wise Approach to Medical and Surgical Management. Operative Techniques in Otolaryngology - Head and Neck Surgery 12,1:34-39, 2001

Georgitis JW: Nasal Hyperthermia and Simple Irrigation for Perennial Rhinitis. Chest 106,5:1487-1491, 1994

Grossan M: Irrigation of the Child’s Nose. Clinical Pediatrics 13,3:229-231, 1974

Grossan M: The Saccharin Test of Nasal Mucociliary Function. The Eye, Ear, Nose and Throat Monthly. 54:415-417, 1975

Manning SC: Pediatric Sinusitis. Otolaryngologic Clinics of North America. 26,4:623-637, 1993

Rachelefsky GS, Slavin RG, Wald ER. Sinusitis: Acute, Chronic - and Manageable. Patient Care. February 28, 1997 pp 105-117

Salvin RG, Cannon RE, Friedman WH, Palitang E, Sundaram M: Sinusitis and Bronchial Asthma. Journal of Allergy and Clinical Immunology. 66,3:250-257, 1980.

Seaton T: Hypertonic Saline for Chronic Sinusitis. The Journal of Family Practice. 47,2:94-96

Talbot AR, Herr MH, Parsons DS. Mucociliary Clearance and Buffered Hypertonic Saline Solution. Laryngoscope. 107:500-503, 1997

Tomooka LT, Murphy C, Davidson TM: Clinical Study and literature Review of Nasal Irrigation. The Laryngoscope. 110:1189-1192, 2000.

Virant FS: A Guide to Therapeutic Interventions for Rhinosinusitis in Children. The Journal of Respiratory Diseases for Pediatricians. 4,1:8-14, 2002

Zeiger RS, Schatz M: Chronic Rhinitis: A Practical Approach to Diagnosis and Treatment. Immunology & Allergy Practice. 4,4:26-35

Allergy and Asthma Center of Rochester, Michigan: Medical Conditions: Rhinitis and Pregnancy. Web site Jan 2003

Pediatric Allergy Immunology 2003 Apr;14(2):140 in Pediatric Notes 2003 Jun 26;27(26):103

David Shoseyov, MD; Haim Blbl, MD; et al. Journal of Allergy and Clinical Immunology 1998; 101:602-5 . Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis.

Diane G. Heatley, MD; Kari E. McConnell, RN, CORLN; Tony L. Kille, BS; Glen A. Leverson, PhD Presented at the annual Meeting of the American Academy of Otolaryngology- Head and Neck Surgery, Washington DC. 9/25/00. ; Nasal Irrigation for the alleviation of sinonasal symptoms.

Ray NF, Baraniuk JN, Thamer M, et al.: Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis and other airway disorders. J Allergy Clin Immunol 1999; 103:408-14.

McCaig LF, Hughes JM; Trends in antimicrobial drug prescribing among office-based physicians in the United States JAMA 1995; 273:214-9.

CDC, Vital and Health Statistics, Current Estimates from the National Health Interview Survey, 1994 (U.S. Department of Health and Human Services, Public Health Service, National Center for Health Statistics): DHHS Pub. No. PHS 96-1521, December 1995.

Kaliner MA, Osuguthorpe JD, Fireman P, et al. Sinusitis bench to bedside: current findings, future directions. J Allergy Clin Immunol 1997; 99:S829-47.

Druce HM, Adjuncts to medical management of sinusitis; Otolaryngol Head Neck Surg 1990; 103:880-3.

Zieger RS. Prospects for ancillary treatment of sinusitis in the 1990's. J Allergy Clin Immunol 1992; 90:478-93.

Talbot AR, Herr TM, Parsons DS. Mucocilliary clearance and buffered hypertonic saline solution. Laryngoscope 1997; 107:500-3.

Robinson M, Hemming AL, Regnis JA et al. Effect of increasing doses of hypertonic saline on muccociliary clearance in patients with cystic fibrosis. Thorax 1997; 52:900-3.

Homer JJ, Dowley AC, Condon L, El-Jassar P, Sood S. The effect of hypertonicity on nasal mucociliary clearance. Clin. Otolaryngol 2000; 25:558-60.

Homer JJ, England RJ, Wilde AD, Harwood GRJ, Stafford ND. The effect of pH of douching solution on mucociliary clearance. Clin Otolaryngol 1999; 24:312-5.

Heatley DG, McConnell KE, Kille TL, Leverson GE Nasal irrigation for the alleviation of sinonasal symptoms. Otolaryngol Head Neck Surg 200l; 125:44-8.

Tamooka LT, Murphy C, Davidson TM. Clinical study and literature review of nasal irrigation. Laryngoscope 2000; 110:1189-93.

Taccariello M, Parikh A, Darby Y, Scadding G. Nasal douching as a valuable adjunct in the management of chronic rhinosinusitis. Rhinology 1999. 37:29-32.

Bachmann G, Hommel G, Michel O. Effect of irrigation of the nose with isotonic salt solution on patients with chronic paranasal sinus disease. Eur Arch Otorhinolaryngol 2000; 257:537-41.

Shoseyov D, Bibi H, Shai P, Shoseyov N, Shazberg G, Hurvitz H. Treatment with hypertonic saline versus normal saline wash of pediatric chronic sinusitis. J Allergy Clin Immunol 1998; 101:602-5.

Rabone SJ, Saraswati SB. Acceptance and effects of nasal lavage in volunteer woodworkers. Occup Med 1999; 49:365-9.

Holmstrom M, Rosen G, Walander L. Effect of nasal lavage on nasal symptoms and physiology in wood industry workers. Rhinology 1997; 35:108-12.

Ware JE, Kosinski M, Keller SD. A 12-item short-form health survey: construction of scales and preliminary test of reliability and validity. Med Care 1996;34:220-6.

Benninger MS, Senior BA; The Development of the rhinosinusitis disability index. Arch Otolyryngol Head Neck Surg 1997; 123:1175-9.

Guyatt GH, Bombardier C, Tugwell P. Measuring disease-specific quality of life in clinical trials. CMAJ 1986;134:889-95.

Senior BA, Glaze C, Benninger MS. Use of the Rhinosinusitis Disability Score (RSDI) in rhinologic disease. American Journal of Rhinology 2001;15:15-20.

Deyo RA,.Patrick DL. The significance of treatment effects: The clinical perspective. Medical Care 1995;33:AS286-AS291.

Redelmeier DA, Guyatt GH, Goldstein RS. Assessing the minimal important difference in symptoms: A comparison of two techniques. J Clin Epidemiol 1996;49:1215-9.

Samsa G. How should the minimum important difference for a health-related quality-of-life instrument be estimated? Medical Care 2001;39:1037-8.

Jaeschke R, Singer J, Guyatt GH. Measurement of health status: Ascertaining the minimal clinically important difference. Controlled Clinical Trials 1989;10:407-15.

Bellamy N, Carr A, Dougados M, Shea B, Wells G. Towards a definition of "difference" in osteoarthritis. J Rheumatology 2001;28:427-30.

Powell CV,.Kelly A-M. Determining the minimum clinically significant difference in visual analog pain score for children. Annals of Emergency Medicine 2001;37:28-31.

Todd KH,.Funk JP. The minimum clinically important difference in physician-assigned visual analog pain scores. Academic Emergency Medicine 1996;3:142-6.

Wells GA, Tugwell P, Kraag GR, Baker PR, Groh J, Redelmeier DA. Minimum important difference between patients with rheumatoid arthritis: the patient's perspective. Journal of Rheumatology 1993;20:557-60.

Wendeler HM, Muller J, Dieler R, Helms J. Nasenspuling mit isotoner Emser-Salz-Losung bei chronischer rhinosinusitis. Otorhinolaryngol Nova 1997; 7:254-8.